Jason Gaglia, a diabetes expert at the Joslin Diabetes Center in Boston. Gaglia in Boston said price would be critical in determining its uptake both among U.N) Januvia will report later in 2018. “Once an oral is available I think there will be significant interest in it.Chief Science Officer Mads Krogsgaard Thomsen said Novo would pay close attention to such factors as it tries to reach the three-quarters of diabetics who are not yet on injections. What’s more, the drug must be in close contact with the stomach wall, which means patients cannot eat for 30 minutes after taking it and the pill can also cause nausea, raising questions about its practicality.That represents a life-line for Novo as it tries to differentiate itself in diabetes at a time when its smaller biopharma division is also struggling, prompting last month’s abortive attempt to buy Belgian biotech Ablynx (ABLX.BR). “The highest limit of where we could consider taking the pricing would be injectable GLP-1 and the lowest level would be somewhere in between current oral drugs and injectable GLP-1,” Thomsen said.. Still, the devil will be in the details of the 10 Phase III trials, the first of which will deliver results this quarter.Novo’s oral semaglutide medicine is important for ensuring the group’s long-term growth - a critical mission after 2017 results last week revealed mounting price pressure in a crowded market targeting the world’s 450 million diabetics.”
That may be sour grapes by Novo’s arch-rival, whose own work on developing an oral GLP-1 is only at the preclinical stage. But the needle is still a barrier.O), which has a product in early-stage trials.The once-daily pill belongs to a blockbuster class of treatments known as GLP-1s that stimulate insulin production, the first of which were derived from the venomous bite of North America’s Gila monster lizard.If Novo gets over the pricing hurdle, Bailey and Gaglia believe the new pill is set to reshuffle treatment regimens, with oral semaglutide being used as a second or third treatment option after cheap, generic metformin.Eli Lilly research chief Jan Lundberg told analysts last week: “It’s really a sub-optimal oral agent.
LATE BREAKFASTBut oral semaglutide is no simple tablet.Denmark’s Novo Nordisk wants to prove it wholesale ceramic alkali pump for sale can transform the diabetes market with a pill.SHUFFLING TREATMENTSDoctors hope oral semaglutide will provide a new weapon to tackle diabetes earlier with a highly effective therapy.Today, GLP-1s are embraced as a highly effective diabetes therapy and semaglutide, which was approved as a once-weekly injection in December, has out-gunned rivals in efficacy. Rivals, especially Eli Lilly (LLY.Getting this far with oral GLP is already a notable achievement, especially after an earlier oral insulin project was abandoned as uneconomic in 2016. But Clifford Bailey, professor of clinical science at Britain’s Aston University and Dr.Novo’s nearest rival in developing an oral GLP-1 is Israel’s Oramed (ORMP. Others are more cautious but investors overall are betting oral and injectable semaglutide combined will supply around two-thirds of Novo’s revenue growth over the next five years, according to
Thomson Reuters consensus data. So far, all have been injections. “There is resistance in some patients to move to an injectable medication,” said Dr. “It will certainly be welcomed by those patients who prefer to go without their breakfast for half an hour rather than have an injection,” said Bailey. insurers and cost-conscious European healthcare systems. Representational Image. (Photo: Pixabay) LONDON: After nearly a century building a company worth $125 billion based on injectable drugs, Denmark’s Novo Nordisk (NOVOb. The size of the benefit will feed into Novo’s final pricing decision.Most analysts expect oral semaglutide to beat these rivals in controlling both blood sugar and weight. Key trials against Lilly and Boehringer Ingelheim’s pill Jardiance and Merck & Co’s (MRK.But making patients wait half an hour for breakfast could affect adherence and is a concern for investors - as is the question of what Novo will charge for a drug that may perform as well as a pricey injection but looks like rival pills that cost half as much. “If we get the balance between the drug’s profile and the drug’s price and market access right then we can do phenomenally well,” he told Reuters.
This is a big, complex molecule, known as a peptide, which would normally be destroyed by stomach acid and it requires protection with a special compound to boost absorption. While diabetics with advanced disease need daily insulin shots, those at a less serious stage start on simple tablets, with GLP-1s added as a potent new option since 2005.CO) - the world’s biggest insulin maker - wants to prove this year it can transform the diabetes market with a pill.S.N), are watching Novo’s final-stage oral semaglutide trials closely, ahead of the drug’s potential 2020 launch.”If the data stack up from 10 pivotal Phase III studies reporting results in 2018, the new drug could grab more than $5 billion in annual sales, Deutsche Bank analysts believe
Last monsoon, it was observed that areas like Cuffe Parade, Worli and Shivaji Park which never saw water logging in the past had minor water logging due to metro 3 work being carried out.As per authorities, metro 3 work is being carried out 18 to 25 metres underground. The work is being carried out underground and it is necessary that rain water is pumped out”.Ashwini Bhide, managing director, MMRC, said, “We have installed 340 de-watering pumps along the entire corridor starting from Cuffe Parade to Seepz to avoid water logging.
The BMC’s storm water drains department in its pre-monsoon inspection of metro 3 construction sites had informed the MMRC to take necessary precautions to avoid water logging, which included installation of de-watering pumps. This year, MMRC has installed de-watering pumps before the onset of monsoon and so far, no water logging complaints have been received,” said deputy municipal commissioner (zone one), Harshad Kale. This choked the storm water drains causing water logging at several locations in south Mumbai.
The metro 3 (Colaba-Bandra-Seepz) corridor is completely underground and work is being carried out in full swing. (Photo: Representational/PTI) Mumbai: To avoid instances of water logging in south Mumbai due to the ongoing wholesale ceramic alkali pump metro 3 construction work, the Mumbai Metro Rail Corporation (MMRC) has installed 340 de-watering pumps at metro 3 construction sites. As per authorities, metro 3 work is being carried out 18 to 25 metres underground.
Last monsoon, it was observed that areas like Cuffe Parade, Worli and Shivaji Park which never saw water logging in the past had minor water logging due to metro 3 work being carried out. “On June 8 during the last monsoon, it was observed that water from metro 3 construction sites filled with mud and cement particles had been released into BMC drains
Adding that Kim will then disappear with speculations of him living a new secret life in China.Craig Hamilton-Parker, the self-proclaimed prophet who predicted Hillary Clintons resignation from politics in 2017 has some pretty glum predictions for 2018 too, including: including an attack on North Korea, a chemical weapons attack on a major European city and the fall of the worlds economy.• US will rent nuclear weapons to Japan.• When the Euro crashes Denmark and Italy will follow Britains path and leave the European Union.The psychic who predicted disastrous events like Donald Trumps election and Britains exit from the European Union has more terrifying predictions for 2018.TERRORISM AND WORLD CONFLICT PREDICTIONS:• A world flu epidemic, possibly linked to biological warfare started by North Korea or a terrorist group.• The UK and US will be hit by the weak Euro but their economies will bounce back quickly and the pound and dollar will once again be seen as good investment opportunities for international money, investment.ENVIRONMENTAL PREDICTIONS:• Mount Vesuvius in Italy will erupt and Naples will be evacuated..•
The US will lose trade in the East as China and Russia form a military and economic alliance in response to the North Korean crisis and US protectionism.He wrote on his blog: Many of the above predictions are pretty gloomy but I feel that there will be a simultaneous growth in spirituality for the people of the world that will now start to lead us into a Golden Age.US PREDICTIONS:• There will be an attempt to impeach Donald Trump by mid 2018, but it will fail which will end up making him more popular.• A well-known American company will be involved in a massive Bitcoin fraud, which will be uncovered and thwarted.• There will be an increase in seismic activity - including places that have been tremor free for 1,000 years - with one very serious earthquake in New Zealand.• A US warship will be sunk by a mine or terrorist operation.• The Mexico border wall will not be built, however there will be drones and sensors to do the job. The funds will be intended for terrorism and war.• There will be record hurricanes in the Caribbean.The psychic wrote on his blog: 2018 will be a year of political turmoil and environmental crisis caused by dramatic and unprecedented weather. It could be either London or Berlin, or both.• Kim Jong Un will be deposed by his own people and he will go missing, with some claiming he is living a secret new life in China.The psychic has predictions for the world with topics ranging from terrorism, the economy and the environment.
Conflict and hardship plus growing environmental problems will bring good people together and ignite a desire to seek the true purpose of human life.• Terrorists will make an airborne chemical weapon gas attack by multiple drones on a European capital city.Among his predictions he also envisions Prince Harry and Meghan Markle will announce their engagement, New Zealand suffering from another severe earthquake, a failed attempt at impeaching Donald Trump and the eruption of a volcano near Naples.• A chemical weapon attack on a school will be thwarted at the last minute.• Japan will pay to hire American missile defence services.While most of his predictions are gloomy, there is a silver-lining, Parker has ceramic alkali pump Suppliers predicted that Kim Jong Un will be overthrown by his people after US forces strike a key trade route.• The southern seas will be impassable in places due to a massive ice shelf breaking from the Antarctic.ECONOMIC PREDICTIONS:• The Euro will crash in 2018, and by the end of the year and into 2019 riots will take place because of the steep economic decline.• A trade embargo with North Korea will fail and the US will strike at railway line and bridge to disrupt imports.• Trump will initiate a massive trade deal with Britain right before Bexit, leaving the EU shaken