The sensational killings that have rocked San Francisco appear to be unrelated except in their brutality. But detective Lindsay Boxer senses there's some thread connecting them all. She calls her friends in the Women's Murder Club together to see if they can discover what it is. Surely some clue has been overlooked by their bosses and male colleagues.

Working with Chronicle reporter Cindy Thomas, Assistant District Attorney Jill Bernhardt, and medical examiner Claire Washburn, Lindsay discovers that there is indeed a link. The victims were of different ages, lived in different locations, and were killed with different weapons. But each had a close relative in a particular profession, a profession that sends a chill through Lindsay's heart.

The partners in the Women's Murder Club realize that this killer is after something unspeakable, something deeper than revenge, and that the next target could be one of them. They deduce where the killer is likely to strike next and bait a trap that can't be resisted. But if their calculation is wrong, the consequences will be lethal. And there will be no second chance.