The "parental unit" started a private investigation business when Dad retired from police work. His wife assists him and their two daughters, Isabel, (Izzy) a 30-year-old with a habit of being arrested, and Rae, a 15-year-old Cheetos-loving teen, would like to think that they help out in the family business. Especially where Izzy is concerned, this is a stretch. Brother David is a successful attorney who has nothing to do with the family enterprise. He has troubles of his own. Izzy has been living in the apartment of a friend while he is away. When he returns unexpectedly, it quickly becomes clear that being roommates with an old, cigar-smoking, poker-playing, big drinker isn't going to work.

Izzy moves home temporarily and then the fun begins. She decides that their new next door neighbor, John Brown, whose landscape gardening business she judges to be a cover, is somehow making women disappear. She gets herself invited to dinner, discovers a locked room, believes his name is phony, follows him everywhere, has a restraining order against her, and still she can't let it go.

Meanwhile, Rae has befriended a great guy, a cop named Henry Stone, who is almost too good to be true. The ball keeps rolling faster and faster with David's problems, her parents' frequent vacations, which they refer to as "disappearances," and the fact that everyone in the family has secrets from one another. If there is any curse at work here, it is that all the family members are terminally nosy.