A leading neuroscientist explores with authority, with imagination, and with unparalleled mastery how the brain constructs the mind and how the brain makes that mind conscious. Antonio Damasio has spent the past thirty years researching and and revealing how the brain works. Here, in his most ambitious and stunning work yet, he rejects the long-standing idea that consciousness is somehow separate from the body, and presents compelling new scientific evidence that posits an evolutionary perspective. His view entails a radical change in the way the history of the conscious mind is viewed and told, suggesting that the brain’s development of a human self is a challenge to nature’s indifference. This development helps to open the way for the appearance of culture, perhaps one of our most defining characteristics as thinking and self-aware beings.