Dr. John Gladstone, a scientist in Victorian London, is thrust into their world after his carriage runs over a young man of angelic beauty named Niccolo. When Niccolo kidnaps Gladstone's child and vanishes, the doctor must go in pursuit, with the help of his daughter, Ursula, who is enticed by the lure of eternal life, and Lady Hespeth, whose demure exterior hides a dangerous obsession. Why are the vampires taking children, and what is the connection to Gladstone's experiments with a deadly virus? And how can he possibly prevail against a race of immortal beings with power and intelligence infinitely beyond his own?

Michael Talbot's The Delicate Dependency (1982) is often cited as one of the best vampire novels ever written. This highly anticipated new edition, the first since the book's original publication, includes a new foreword by Jillian Venters.