Hardbound. This 19-chapter volume summarizes the current status of our understanding of RNA, with particular emphasis on the chemistry of this key biological molecule. The various RNAs covered are messenger RNA, ribosomal RNA, transfer RNA and RNA enzymes (ribozymes). The different chapters detail biophysical and chemical methods to investigate RNA structure and function, the synthesis of native and modified RNAs and several chapters reviewing the latest advances in our understanding of the vast array of biological processes in which RNA is involved.The first five chapters deal with different approaches available to study RNA structure, covering NMR solution studies of secondary structure, thermodynamics, X-ray crystallographic approaches, RNA dynamics and the role of RNA structures in RNA: protein interactions.Three chapters are focused on RNA chemistry covering chemical and enzymatic probes for RNA, chemical RNA synthesis and the chemist