This is a comprehensive system-based review in clinical radiology, covering major diseases encountered in everyday clinical practice. A case-orientated approach is used, with high quality images from the latest available imaging modalities including MRI of the breast and cardiovascular system, CT colonography, amongst others. Each chapter is dedicated to a specific functional system and begins by outlining different clinical cases, each with a concise clinical history and initial imaging, followed by explanation of the pertinent imaging findings. The second part of each case contains a discussion on the list of important differential diagnoses to consider and the role of different imaging modalities in the presenting problem. The latter shows how information derived from different imaging modalities (including xrays, fluoroscopy, CT, MRI, nuclear medicine / PET-CT, angiograms, etc.) can help refine and prioritize imaging differentials. For each clinical case, the novel incorporation of cine images (accessible via QR codes) provides a new type of learning experience - one that simulates the reality of how medical imaging are interpreted using serial images with spatial reformatting rather than static planar images.