Lu Anne Henderson was a beautiful 15-year-old girl in Denver in 1945 when she met Neal, a fast-talking hurricane of male sexuality and vast promises. The two married, and soon they were hanging out with a group of would-be writers, including Jack Kerouac and Allen Ginsberg. Lu Anne became the secret link between Kerouac and Cassady, helping to ignite the Beat Generation, and giving Kerouac material for one of the seminal novels of the 20th century, On the Road.Lu Anne Henderson did not live to see the filming of On the Road by Walter Salles, but One and Only tells how Twilight’s Kristen Stewart, through her work with both Nicosia and Anne Marie Santos (Lu Anne's daughter), came to find the key to playing Lu Anne in the film.