A Jack the Ripper type killer is murdering male prostitutes, with one exception that causes police to ask doctors Jill Raney and David Levine to help investigate. Jill is horrified to hear that a young woman is found brutally attacked, the marks of her assault the only link to three other horrific murders: a transgender woman, a transvestite, and a 17-year-old hustler. So nasty are the kills of those three born-males that the psychopath seems to be saying, they're all males...FROM HELL he scrawls, taunting the NYPD with the original Jack the Ripper's 1888 letter to the police. He wears gloves, disguises, and leaves no physical evidence. The police ask "one small favor" of Jill and David, friends and - until now, detectives on their own. "No warrant? No problem!" had been their mantra...until their relationship with the cops got crazy; led to exhaustion, conflict, and not enough time to spend with their adored little son, Jesse.But they share the horror that grips the country and agree to help, thus plunging into a terrifying maze of psycho-sexual obsession and madness.