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review 2019-03-20 20:32
Great Read
Protecting My Heart (Valentine Bay Book ... Protecting My Heart (Valentine Bay Book 1) - Melanie Shawn

Protecting My Heart by Melanie Shawn is a laugh out loud contemporary romance.  Ms. Shawn has provided readers with a well-written book.  The characters are phenomenal and the dialog is outstanding.  Ella and Donovan got married during a drunken post-high school celebration in Vegas.  They shrugged it off thinking it didn't count since they used their fake ID cards.  It only took 15 years to learn they had used their real ID and were married.  Donovan and Ella's story is loaded with drama, humor and spice.  I enjoyed reading Protecting My Heart and look forward to reading more from Melanie Shawn soon.  Protecting My Heart is book 1 of the Valentine Bay Series but can be read as a standalone.  This is a complete book, not a cliff-hanger.

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text 2019-03-19 18:50
Ooh, a package
Total Eclipse of the Eternal Heart - Syundei 春泥

I just got notified that this has been delivered. It's by the same author who wrote/illustrated Go For It, Nakamura! - this looks to be a good deal darker than that work, but I'm hoping it's just as enjoyable.

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text 2019-03-18 10:28
Acute Heart Failure Therapeutics Market Checkout The Unexpected Future 2026

Acute heart failure (AHF) is a progressive condition, in which, the heart muscle is unable to pump enough blood through the heart to meet body’ optimal blood and oxygen level. Congestive heart failure is type of heart failure which requires timely medical attention. Moreover, distinguish between acute and chronic heart failure is important from a clinical standpoint, on which further medication depends. For this, N terminal proB-type natriuretic peptide levels are used for distinguishing acute versus chronic left ventricular dysfunction. An elevated levels of natriuretic peptide were present in patients with acute heart failure compared to those with chronic heart failure patient.


Heart failure symptoms vary widely from person to person, depending on types of heart failure patient. The main symptoms of heart failure are caused due to fluid accumulation or congestion and poor blood flow to the body. Symptoms caused by fluid accumulation or congestion includes shortness of breath, weight gain, coughing, swollen ankles, legs or abdomen, while dizziness, rapid heart rate, and fatigue are symptoms associated with reduced blood flow to parts of the body.


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Acute Heart Failure (AHF) Therapeutics Market – Drivers


The global acute heart failure therapeutics market is expected to witness significant growth due to approval of new drugs. For instance, in July 2015, Novartis received U.S. Food and Drug Administration (FDA) approval for their Entresto(TM) (sacubitril/valsartan) tablets on the treatment of heart failure with reduced ejection fraction. Entresto is indicated to reduce the risk of cardiovascular death and heart failure hospitalization.


Furthermore, robust pipeline of drugs over the forecast period (2018-2026), is another factor driving growth of acute heart failure therapeutics market. For instance, in March 2017, Cardioxyl Pharmaceuticals’ CXL-1427: a novel nitroxyl (HNO) donor (prodrug), which now operates under the Bristol-Myers Squibb Company (after Cardioxyl Pharmaceuticals’ acquisition by Bristol-Myers Squibb in December 2015); is present in Phase 2 clinical development phase. CXL-1427 is indicated to use as an intravenous treatment for acute decompensated heart failure (ADHF). Successful completion and further launch of Bristol-Myers Squibb’s innovative drug in future, will help to boost the acute heart failure (AHF) therapeutics market growth during the forecast period.


Acute Heart Failure (AHF) Therapeutics Market – Regional Analysis


Geographically, the market is segmented into North America, Latin America, Europe, Middle East, Asia Pacific, and Africa. North America is expected to hold dominant position in global acute heart failure (AHF) therapeutics market, due to high prevalence of acute heart failure cases, in this region. For instance, according to Centers for Disease Control and Prevention (CDC), June 2016, around 5.7 million adults in the U.S. suffered from heart failure, in 2016. Moreover, about half of the people who develop heart failure die within 5 years of diagnosis.


Acute Heart Failure (AHF) Therapeutics Market – Competitive Landscape


Some of the key players in this market are Novartis AG, Cardiorentis AG, Bristol-Myers Squibb Company, Amgen Inc., Bayer AG, Cytokinetics, Inc., Merck & Company, Inc., Ono Pharmaceutical Co., Ltd., and Pfizer Inc., among others. Key players in the marker are engaged in development of new drugs for acute heart failure (AHF). These players are incorporating collaboration strategies to remain competitive in the market.


Acute Heart Failure (AHF) Therapeutics Market – Taxonomy


By Disorder Type:


Right-sided Heart Failure

Left-sided Heart Failure: Systolic Failure, Diastolic Failure

Congestive Heart Failure


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review 2019-03-18 02:47
A Fist Around the Heart: Two Sisters, Two Cities. One Train, One Life.
A Fist Around the Heart - Heather Chisvin

Actual Rating: 3.25 stars


I have delayed this book for sooo long. I just never had the energy to pick it up again once I've put it down. But finally, finally, I've finished it (last year actually before 2018 ended) and I've come with, you called it, a review.


A Fist Around the Heart is about the relationship of two sisters, Anna and Esther, who were forced to migrate to Winnipeg by their mother to escape the chaos in Russia. Since then, they were forced to live with their mother’s employers as their apparent guardians. A lot has happened in both their lives during the years that have passed. One day, after visiting Anna, there was news that Esther killed herself by letting herself get run over by the train that was supposed to be her ride home to Winnipeg.


Throughout the book, it shows the hardships Anna experienced, both living alone in New York and living with her sister, parents, and guardians. It deals with loss, pain, trauma, grief, and mental illness. But there were also parts which showed friendship, family, and support but being independent at the same time.


A Fist Around the Heart was an interesting read for me. The book's pace was just good enough for me and I understood what was going on. I could distinguish which were the flashbacks and the ones in the present day. I liked how some parts were kind of realistic and how I imagined they would be. I also learned some new things about history when I read this book.


I liked how the story was detailed but not too detailed. There were still some questions that were unanswered which was slightly disappointing because there was no complete closure about some things. But all in all, I guess, the end was patched alright. The characters were better than the plot so moving on...


Let's talk about the sisters... I could somehow relate to Anna's grief and I sympathize for her. All throughout the book, I admired her for being such a strong, independent woman. She may not had it easy but she got through. As for Esther, she made me think of how she and her sister have had it rougher compared to my life. She struggled through so much in her life. They both faced lots of challenges but they got through because they had each other. Or at least, Esther did. She was kind of dependent to Anna and that showed how fragile and vulnerable she is. Lucky she had Anna by her side as her support system.


Ugh, this book just makes me want to have a sister even more! The support, love, and concern represented by the two sisters frustrates me because I don't see that with me and my brothers. I hope that someday I could find someone who would consider as a sister to me and me to her.


Trigger warning: mentions of suicide and mental illness


Note: Thank you to NetGalley for my copy of A Fist Around the Heart.

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review 2019-03-18 02:36
Dark Heart: 1 (A Cooper & Quinn Crime Thriller) - Catherine Lee


The assault on my overloaded kindle continues. This book has been on there for awhile & its time had come. It's a combination of police procedural & an interesting look at the concept of cellular memory in transplant patients.


Sooo...what if your new heart came from a serial killer? A recent murder victim is discovered to be the killer police have been hunting for 10 years. His donated organs will save a young woman's life but have enormous repercussions for her whole family.


I really liked the procedural aspect of the story. The 2 MC's (cops) were great characters & the plot suitably twisty. For 80% of the story I was all in. But I'm afraid I felt let down by the last bit for 2 reasons. One was the ethical dilemma faced by police at the end & how it played out. The other was the inclusion of a personal pet peeve.....instalove. You know, the old I've-known-you-for-5-minutes-and-can't-live-without-you scenario. Erk. The sad thing is the accelerated romance was unnecessary & not integral to the story line. Maybe it could have ended with the blissful couple just going on a first date?


Anyhoo, the rest of the book was a well written & pacy read. If you're a bigger fan of amour, ignore my rant & give this a go.





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