Consider the research purpose of the freezing cryo tube: if the hot plate method is used for female analgesia experiments in females, the test of male rats attached to the hot plate affects the experiment. 2016. Hypertension. This makes the monthly changes of estrogen and progesterone in women very obvious, while the testosterone in men remains stable and high for a long time, so it is believed that more stable data can be obtained for male animals.
Considering the cost of previous experiments or some special experiments, we can give preference to a certain sex for testing. However, recent studies have shown that female mice's various physiological indicators change throughout the hormonal cycle is not greater than that of male mice [2], and even the individual variation of some sex-different phenotypes of male animals is more pronounced than that of female individuals [3] For example, individual differences in androgen levels can affect tumor treatment.5. I hope that after reading this article, you can have a new understanding of gender considerations,
if you have any questions, please leave a message on the public account! References NIH to balance sex in cell and animal studies Female mice liberated for inclusion inneuroscience and biomedical research AlexDayton, et al. Barbital is metabolized faster than female rats, so female rats sleep longer than male rats; it has also been clinically found that sleeping drugs have stronger side effects on women, so in early 2014, the US FDA downgraded these drugs For women's recommended dosage; therefore, the
NIH's suggestion is that the experiments currently used for male animals can be used for females, which means that the effects of gender on experimental results (especially females) should be ignored in animal experiments Animals should include both males and females, and 'gender equality' in animal experiments.
Hubei People's Publishing House, 2016. Tang Hongbin. Animals bite each other; this phenomenon can also cause experimental results to be biased by ignoring gender differences. However, in the study, it was found that experimental animals of different genders have significantly different susceptibility to certain drugs, and their responses to various stimuli are not uniform. Conclusion: