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text 2019-03-18 10:28
Acute Heart Failure Therapeutics Market Checkout The Unexpected Future 2026

Acute heart failure (AHF) is a progressive condition, in which, the heart muscle is unable to pump enough blood through the heart to meet body’ optimal blood and oxygen level. Congestive heart failure is type of heart failure which requires timely medical attention. Moreover, distinguish between acute and chronic heart failure is important from a clinical standpoint, on which further medication depends. For this, N terminal proB-type natriuretic peptide levels are used for distinguishing acute versus chronic left ventricular dysfunction. An elevated levels of natriuretic peptide were present in patients with acute heart failure compared to those with chronic heart failure patient.


Heart failure symptoms vary widely from person to person, depending on types of heart failure patient. The main symptoms of heart failure are caused due to fluid accumulation or congestion and poor blood flow to the body. Symptoms caused by fluid accumulation or congestion includes shortness of breath, weight gain, coughing, swollen ankles, legs or abdomen, while dizziness, rapid heart rate, and fatigue are symptoms associated with reduced blood flow to parts of the body.


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Acute Heart Failure (AHF) Therapeutics Market – Drivers


The global acute heart failure therapeutics market is expected to witness significant growth due to approval of new drugs. For instance, in July 2015, Novartis received U.S. Food and Drug Administration (FDA) approval for their Entresto(TM) (sacubitril/valsartan) tablets on the treatment of heart failure with reduced ejection fraction. Entresto is indicated to reduce the risk of cardiovascular death and heart failure hospitalization.


Furthermore, robust pipeline of drugs over the forecast period (2018-2026), is another factor driving growth of acute heart failure therapeutics market. For instance, in March 2017, Cardioxyl Pharmaceuticals’ CXL-1427: a novel nitroxyl (HNO) donor (prodrug), which now operates under the Bristol-Myers Squibb Company (after Cardioxyl Pharmaceuticals’ acquisition by Bristol-Myers Squibb in December 2015); is present in Phase 2 clinical development phase. CXL-1427 is indicated to use as an intravenous treatment for acute decompensated heart failure (ADHF). Successful completion and further launch of Bristol-Myers Squibb’s innovative drug in future, will help to boost the acute heart failure (AHF) therapeutics market growth during the forecast period.


Acute Heart Failure (AHF) Therapeutics Market – Regional Analysis


Geographically, the market is segmented into North America, Latin America, Europe, Middle East, Asia Pacific, and Africa. North America is expected to hold dominant position in global acute heart failure (AHF) therapeutics market, due to high prevalence of acute heart failure cases, in this region. For instance, according to Centers for Disease Control and Prevention (CDC), June 2016, around 5.7 million adults in the U.S. suffered from heart failure, in 2016. Moreover, about half of the people who develop heart failure die within 5 years of diagnosis.


Acute Heart Failure (AHF) Therapeutics Market – Competitive Landscape


Some of the key players in this market are Novartis AG, Cardiorentis AG, Bristol-Myers Squibb Company, Amgen Inc., Bayer AG, Cytokinetics, Inc., Merck & Company, Inc., Ono Pharmaceutical Co., Ltd., and Pfizer Inc., among others. Key players in the marker are engaged in development of new drugs for acute heart failure (AHF). These players are incorporating collaboration strategies to remain competitive in the market.


Acute Heart Failure (AHF) Therapeutics Market – Taxonomy


By Disorder Type:


Right-sided Heart Failure

Left-sided Heart Failure: Systolic Failure, Diastolic Failure

Congestive Heart Failure


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review 2019-03-18 02:47
A Fist Around the Heart: Two Sisters, Two Cities. One Train, One Life.
A Fist Around the Heart - Heather Chisvin

Actual Rating: 3.25 stars


I have delayed this book for sooo long. I just never had the energy to pick it up again once I've put it down. But finally, finally, I've finished it (last year actually before 2018 ended) and I've come with, you called it, a review.


A Fist Around the Heart is about the relationship of two sisters, Anna and Esther, who were forced to migrate to Winnipeg by their mother to escape the chaos in Russia. Since then, they were forced to live with their mother’s employers as their apparent guardians. A lot has happened in both their lives during the years that have passed. One day, after visiting Anna, there was news that Esther killed herself by letting herself get run over by the train that was supposed to be her ride home to Winnipeg.


Throughout the book, it shows the hardships Anna experienced, both living alone in New York and living with her sister, parents, and guardians. It deals with loss, pain, trauma, grief, and mental illness. But there were also parts which showed friendship, family, and support but being independent at the same time.


A Fist Around the Heart was an interesting read for me. The book's pace was just good enough for me and I understood what was going on. I could distinguish which were the flashbacks and the ones in the present day. I liked how some parts were kind of realistic and how I imagined they would be. I also learned some new things about history when I read this book.


I liked how the story was detailed but not too detailed. There were still some questions that were unanswered which was slightly disappointing because there was no complete closure about some things. But all in all, I guess, the end was patched alright. The characters were better than the plot so moving on...


Let's talk about the sisters... I could somehow relate to Anna's grief and I sympathize for her. All throughout the book, I admired her for being such a strong, independent woman. She may not had it easy but she got through. As for Esther, she made me think of how she and her sister have had it rougher compared to my life. She struggled through so much in her life. They both faced lots of challenges but they got through because they had each other. Or at least, Esther did. She was kind of dependent to Anna and that showed how fragile and vulnerable she is. Lucky she had Anna by her side as her support system.


Ugh, this book just makes me want to have a sister even more! The support, love, and concern represented by the two sisters frustrates me because I don't see that with me and my brothers. I hope that someday I could find someone who would consider as a sister to me and me to her.


Trigger warning: mentions of suicide and mental illness


Note: Thank you to NetGalley for my copy of A Fist Around the Heart.

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review 2019-03-18 02:36
Dark Heart: 1 (A Cooper & Quinn Crime Thriller) - Catherine Lee


The assault on my overloaded kindle continues. This book has been on there for awhile & its time had come. It's a combination of police procedural & an interesting look at the concept of cellular memory in transplant patients.


Sooo...what if your new heart came from a serial killer? A recent murder victim is discovered to be the killer police have been hunting for 10 years. His donated organs will save a young woman's life but have enormous repercussions for her whole family.


I really liked the procedural aspect of the story. The 2 MC's (cops) were great characters & the plot suitably twisty. For 80% of the story I was all in. But I'm afraid I felt let down by the last bit for 2 reasons. One was the ethical dilemma faced by police at the end & how it played out. The other was the inclusion of a personal pet peeve.....instalove. You know, the old I've-known-you-for-5-minutes-and-can't-live-without-you scenario. Erk. The sad thing is the accelerated romance was unnecessary & not integral to the story line. Maybe it could have ended with the blissful couple just going on a first date?


Anyhoo, the rest of the book was a well written & pacy read. If you're a bigger fan of amour, ignore my rant & give this a go.





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review 2019-03-13 02:42
Heart of the Devil (The Forge Trilogy #3) - Meghan March
Wow! We are at the end of the Forge trilogy and what an ending. As I write this review, I have to say I am still in shock with the story evolved. It is a good shock. It’s just that I never expected it to go the way it did. Throughout the first two books, Meghan had me pointed in one direction, but then she dropped that bombshell in the final book. I still have not lifted my jaw from where it dropped. I kept wondering, how did I not see that?
This is not a series you should pick if you have a busy schedule because trust me once you start reading you will be hard-pressed to put it down. So fair warning, proceed with caution.
From the moment I began this series, I found myself caught up in the story and the lives of the characters. I could not get enough. The characters oozed sheer awesomeness. I said this before in my review of book two and I have to reiterate Indy and Jericho are hands down my favourite couple for 2019. They are the ultimate power couple.
The suspense element of the story was well done.  The story had me literally on the edge of my seat as I anxiously waited to see how it would all play out.
The romance is has hot as fire but as sweet as honey. There are scenes that will make you blush and I loved how tender Jericho acted towards Indy. She was the one woman who could bring him to his knees. It was plain as day how much they loved each other, but obstacles kept darkening their path.  I am happy to report that despite the obstacles their love for each other triumphed.
A wonderful series, with awesome characters and a great ending. Fans of Ms. March will love Jericho and Indy. Want a new series to sink your teeth in then the Forge trilogy should be on your list.
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review 2019-03-12 15:16
ARC REVIEW The Beast's Heart by Leife Shallcross
The Beast's HeartThe classic version of Beauty and the Beast as told from the Beast's perspective. What I love about this book, because I do love it, is that this is more like the traditional version of the fairy tale and not Disney's version. Instead of their being an overall villian with an exciting fight scene at the end it's more man vs. self. The internal struggle of Beast fighting with who he perceives himself to be and who he wants to be and adding Beauty (in this case Isabeau) to the mix he wants to be a better person for her all the while trying to show her he's worthy of her love.

The story starts off with Beast in the woods living as an animal would until he's led back to his home and the iron gates lock behind him. Slowly he starts to remember thing and the magic slowly starts to repair the house and gardens. Beast is there so long he loses track of time the enchantment keeping the grounds in an eternal summer. Beast relearns how to dress and act like a man. The details of his curse still remain foggy in his mind all he knows is that a fairy cursed him to be the beast he is inside.

Isabeau comes along quite like she always does, to save her father after he tries to steal a single rose from Beast's gardens after everything else was given freely. In this we see Beast's side of it, when he allowed her father in he was longing for company but changed his mind at the last moment, but he saw into her father's dream a had vision of his youngest daughter. Beast manipulated the situation to bring her to his home; as soon as he did it he felt bad and after she got there he admitted what he did and told her she was free to leave but he was so lonely. So they struck up a deal she stays for a year and keeps Beast company and she will be free to leave after that. Everything else plays out Isabeau has her dreams she keeps to herself but the Beast when he's not with Isabeau is watching her family through his mirror, first out of guilt for what he took from them but then he started to care about them.

Overall, the slow and steady narration of the Beast is wonderful. I loved this version of the original story and I love how she didn't just end it after the curse was broken. Another thing I liked was how Beast didn't know until almost half the year was over that there was a way to break the curse, the details and the why of the curse slowly get revealed to him as he remembers more about his life before the curse. I loved the small details the descriptive narrative was spellbinding, I didn't want to put this book down.



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