The global mice model market involves use of different varieties of mice (inbred, outbred, and conditioned/surgically modified, among others) in the research studies across the globe. Mice models are widely used as research models to study human genes and human diseases. Scientists use mice models to explore various health problems and assure the safety of new medical treatments.

Factors such as ongoing innovations in mice models, continuous support in the form of investments and grants, and growing demand for humanized mice models.

The mice model market is expected to reach USD 1.59 billion by 2021 from USD 1.11 billion in 2016, at a CAGR of 7.5% from 2016 to 2021.

On the basis of type, the mice model market is segmented into inbred mice, genetically engineered mice, conditioned/surgically modified mice, hybrid/congenic mice, outbred mice, and spontaneous mutant mice. The knockout mice models is expected to grow at the highest CAGR during the forecast period. The high growth mice of knockout mice model can be attributed to the popularity of CRISPR Technology for creating gene knockouts, high investments in the development of new and innovative knockout models that also increases the application areas for these models.

On the basis of services, the mice model market is segmented into breeding, quarantine, rederivation, cryopreservation, genetic testing, model in-licensing, and other services such as surgical services, line rescue services, and in vivo pharmacology services. The breeding services segment is expected to command the largest share of the market. The large share of this segment can be attributed to the growing need for expertise in breeding mutant, transgenic, gene-targeted, and other types of mice, resulting in growth in demand for breeding services amongst biomedical and pharmaceutical researchers.

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On the basis of technology, the mice model market is segmented into CRISPR/Cas9, microinjection, embryonic stem cell injection, nuclear transfer, and other technologies (genetically modified sperm-mediated gene transfer, virus/vector-mediated gene transfer, liposome-mediated DNA transfer, electroporation of DNA, biolistics, and TALENs & ZFNs). The CRISPR segment accounted for the largest share of the mice model market in 2016. The large share of this segment is mainly attributed to the fact that CRISPR is the most widely used technique due to the various advantages associated with it, such as ease of design, high efficiency, and relatively low cost.

On the basis of therapeutic area, the mice model market is segmented into oncology studies, immunology and inflammation studies, central nervous system studies (anxiety and other disorders), cardiovascular studies, diabetes studies, and other disease studies (mice models for rare diseases and metabolism & regulatory disorder studies, hematopoiesis, renal and toxicology studies). The oncology studies segment commanded the largest share of the mice model market in 2016. The large share of this segment can primarily be attributed to the growing cancer research activities and increasing innovation in mice models that are tailored to meet cancer research needs.

On the basis of mice care products, the mice model market is segmented into bedding, cages, feed, and other products such as gnotobiotic equipment, water systems, and accessories (washing systems, water purification systems, and sound absorption panels, among others). The cages product segment commanded the largest share of the mice model market in 2016.

Growing use of rat models, regulations & laws formulated for ethical use of animals and increased benefits offered by cryopreservation are the major factor restraining the growth of the market.  Various regulations and laws have been laid down by governments for ensuring ethical use of animals in research activities. Research institutes and companies carrying out studies on animals have to comply with these standards and requirements formulated for animal testing.

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Leading Companies 

The key players in the global mice model market include Charles River Laboratories International (US), The Jackson Laboratory (US), Taconic Biosciences (US), Envigo (UK), Laboratoratory Corporation of America Holdings (US), JANVIER LABS (France), Harbour BioMed (China), TRANS GENIC (Japan), genOway (France), and Horizon Discovery Group (US).

Ongoing innovations in mice models, continuous support in the form of investments and grants, and growing demand for humanized mice models are some of the factors driving the growth of the mice model market.

The mice model market is expanding with the increase in R&D activities in pharmaceutical industries. These mice model are being used in many applications such as oncology studies, immunology and inflammation studies, central nervous system studies (anxiety and other disorders), cardiovascular studies, diabetes studies. 

The global mice model market is expected to reach USD 1.59 billion by 2021 from USD 1.11 billion in 2016, at a CAGR of 7.5% from 2016 to 2021. The market is mainly driven by factors such as ongoing innovations in mice models, continuous support in the form of investments and grants, and growing demand for humanized mice models.

Growing consumption of personalized medicine designed through the use of mice model, drives the global mice model market.

Personalized medicine is the process of developing tailored medications to target individualized treatment and care based on personal and genetic variation. These medicines are designed through the use of animal models, particularly mice models. In this process, immune-deficient models are transplanted with human tissues and the disease expressed is recorded. This is followed by treating the model with a whole series of drugs or gene therapies to find the most suitable treatment, thus generating suitable or personalized medicines for patients.

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Mice model applications in various therapeutic indications such as immunology and inflammation studies, central nervous system studies (anxiety and other disorders), cardiovascular studies, diabetes studies, and other disease studies (mice models for rare diseases and metabolism & regulatory disorder studies, hematopoiesis, renal and toxicology studies) coupled with the ongoing innovations in mice models drive the growth of mice model market.

ONCOLOGY STUDIES

Mice models have significantly contributed to the understanding of cancer biology as they are useful in validating gene functions, identifying novel cancer genes and tumor biomarkers, understanding the molecular and cellular mechanisms underlying in tumor initiation, and providing better clinical models to test novel therapeutic strategies.

IMMUNOLOGY AND INFLAMMATION STUDIES

Mice models are used in immunology and inflammation studies as they help assess the physiological relevance of an experimental finding. They also assist in identifying the function of newly identified surface receptors in host defense as well as the developmental consequences of a disturbed signaling pathway or removing a transcription factor.

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DIABETES STUDIES

Mice are considered to be excellent experimental models for understanding the complex genetic basis of diseases such as diabetes. Due to the growing prevalence of diabetes globally, it has become important to study the mechanism of the disease. It is difficult to study disease conditions in humans due to factors such as genetic heterogeneity and lack of controlled lifestyles. Mice models are therefore used in diabetes research.

CARDIOVASCULAR STUDIES

Mice are commonly used as preferred models for cardiovascular research due to advantages such as ease of handling and low procedure costs. Mice models are genetically modified as per the study requirement. For instance, the mice model for atherosclerosis is based on genetic modifications of lipoprotein metabolism with additional dietary changes. The low-density lipoprotein receptor-deficient mice (LDLR-/- mice) and apolipoprotein E-deficient mice (apoE-/- mice) are the most widely used mice models for atherosclerosis.

CENTRAL NERVOUS SYSTEM (CNS) STUDIES

Mice models serve as suitable animal models for detailed and accurate analysis of the mechanism of human neurodegenerative diseases. They help in the development and evaluation of new therapeutic strategies. Transgenic mice models are available for several neurological human conditions such as prion diseases, human retroviral diseases, Alzheimer’s disease, motor neuron diseases, and anxiety.

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