This short story is exactly what the title says it's about: talking to girls at a party. What sets it apart from other how-to-pick-up-girls guides is it doesn't show how to pick up girls because it's actually a story, and the girls are not like other girls. And by that, I don't mean they're not like other girls (click for further explanation).
As far as Gaiman short stories go, I like this one about as much as the others. It's funny, smart, and unusual, like its forerunners. What's different here is its purposefully stumbling awkward humor.
The year is 1970-something and the place is somewhere in the UK. Vic and Enn are two teenage boys experiencing a teenage rite of passage; they're invited to a party and they're determined to interact with girls. However, Enn is inexperienced and has no idea what to expect. So naturally he comes off as awkward and self-conscious (and hilarious but in that secondhand embarrassment kind of way). Vic, on the other hand, is a bit more of a smooth operator.
The girls are portrayed as exchange students, and the boys don't doubt that for a minute because, like it's been established, they're inexperienced, but we, as more experienced worldly readers, know better. We pick up on the nuances and various moments between Enn and Vic and the girls that don't seem quite right because they're more awkward than the usual teenage awkwardness.
Half of the fun of this story is in the boys trying to figure out how to talk to these girls all the while figuring out they're not like other girls. Literally.